Emsam

Please send the items checked to the address provided above. Please provide a complete copy of all medical records, rather than a summary. Thank you for your time and promptness. Records of care from to to include anything that could have a bearing on my fertility. ? ? ? Medical records operative reports Laboratory reports Hysterosalpingogram x-rays and reports Biopsy slides Other please specify.
Figure 5. Effect of AT1 receptor antagonist on macrophage infiltration in cerebral vessels. A, Arrowhead points to macrophage adhering to microvessel endothelium a ; . Bar 20 m. White arrowheads point to flattened macrophages closely attached to the microvessel wall b, c, d ; . Arrows point to rounded macrophages detached from the vessel wall c ; . Bar 50 m. B, Arrowhead points to macrophages adhering to middle cerebral artery endothelium. Bar 50 m. C, Arrowheads point to macrophages adhering to endothelium of carotid artery g ; . Arrows mark medial layer of carotid artery. Bar 20 m. D, Number of perivascular macrophages in brain microvessels left ; and endothelium-attached macrophages in carotid artery right ; . Results are mean SEM. * P 0.05 vs vehicle-treated WKY rats or candesartan-treated SHR. The unfortunate part of the emsam for me is that i have a rather severe allergic reaction to the patch. Evaluated, but they may have a possible future role in predicting outcomes and guiding therapy. They include tumor suppressor gene p53, oncoprotein bcl-2, ras oncogene p21, proliferation index rate of cell division ; and other genetic markers involved in the regulation of the cell cycle. The rapid advance of gene-mapping technology with gene-expression profiling is likely to confirm in the near future some more clinically relevant genetic markers. From having to watch diet and other medications that could also increase tyramine levels or stimulate release of norepinephrine. At higher doses, selegiline inhibits both MAO-A and MAO-B. The Emssm patch will be available in doses equivalent to 6 mg, 9 mg, and 12 mg absorbed in a 24-hour period. Clinical trials data on the 6 mg dose showed no inhibition of MAO-A, and therefore the lowest dose will not be labeled with patient warnings regarding diet. However, both the 9 mg and 12 mg patches will carry dietary warnings. In addition, Somerset and BMS have agreed to develop a patient-education campaign regarding dietary modifications necessary when using the two higher doses. The companies have pledged to monitor reports of adverse events. In clinical trials, the most common treatment-emergent adverse events included skin reaction to the patch 24 percent with Emsam, 12 percent with placebo ; , headache 18 percent versus 17 percent ; , insomnia 12 percent versus 7 percent ; , and diarrhea 9 percent versus 7 percent ; . Alexander Bodkin, M.D., chief of the Clinical Psychopharmacology Research Program at Harvard University McLean Hospital, noted that the need for other treatment options "is indeed great: some 30 percent of all patients who seek treatment and receive SSRIs or SNRIs do not respond to the medication. Many then end up taking combinations of two or more antidepressants in an attempt to get an effect on all three monoamines, such as an SSRI plus bupropion or CNS stimulants. With selegiline, all three monoamines are covered, and the data show onset of action is very quick--within the first day to seven days." Bodkin was a principal investigator on several clinical trials of the Rmsam patch. More information is posted at bms.

Culture Date Lab No. Results Notes: * All dates in the tables that report smears, culture and DST are dates the specimen was collected from the patient. * The sputum collected that led to the patient being registered with MDR-TB if performed and geodon. Estimated Costs and Benefits in Connecticut: Adopting a similar program in Connecticut would require BACT for an estimated 880 waste haulers public and publicly-contracted vehicles, estimated number of vehicles prorated from New Jersey based on population ; . Costs: o Assuming the highest level of BACT a passive diesel particulate filter ; is feasible for every truck, total estimated capital costs equal: 880 trucks * , 500191 .6 million o Assuming that retrofits are phased in over four years between 2007 and 2010, the operating cost of cleaning filters equals: 2008: 220 filters * 0192 0, 000 2009: 440 filters * 0 0, 000 2010: 660 filters * 0 0, 000 2011: 880 filters * 0 0, 000 o Cost Caveats: For some engines, particularly pre-2002 Mack engines, the BACT will be a wire mesh filter or high-performance DOC ; rather than a DPF. These installations are much cheaper, estimated , 000 versus , 500 ; and they do not require annual filter cleanings. Under this option, owners would not be required to repower, rebuild or replace engines, so no additional costs are expected for pre-1991 engines. Benefits: o Pro-rated from New Jersey DEP's benefit assessment estimated annual benefit of 14 tons Estimated annual benefit of regulation in 2010: 5.6 tons reduced; Estimate cumulative benefits of regulation: 42.9 tons reduced.
At about 10 days, EMSAM 20 mg produced a modest 2-fold increase in sensitivity to orally administered tyramine equivalent to oral selegiline and 20 times less than that of tranylcypromine. EMSAM 40 mg produced a change in tyramine sensitivity that was 4 times less than that observed with tranylcypromine, again differentiating EMSAM from traditional, nonselective MAOIs, even at the highest recommended therapeutic dose. Maximum increase in tyramine sensitivity due to EMSAM occurred by about 30 days. There was a 2- to 3-fold elevation in the margin of cardiovascular safety of EMSAM when tyramine was administered in food or with food, as opposed to encapsulated tyramine in the fasted state. The volume of food required to increase blood pressure during treatment with EMSAM 20 mg exceeded physical capabilities and paxil. Singh AN. Therapeutic efficacy of flupenthixol decanoate in schizoaffective disorder: a clinical evaluation. Journal of International Medical Research 1984; 12: 17-22.

Emsam cost

In Fiscal Year 2001 02, a bill for repair work amounting to Rs. 41, 600.00 was attached and the amount was paid to Arc Engineers, Builders and Contractors Pvt. Ltd. It is seen that a bill was submitted again in this fiscal year with the reason that it had been omitted previously and that VAT amounting to Rs. 4, 160 was paid. However, 4, 160.00 a certificate showing that the amount of the VAT has been deposited at the concerned office was not presented. As per an agreement made on September 26, 2002 between the National Human Rights Commission and the Informal Sector Service Centre INSEC ; , Kalanki, regional-level seminars were held in October 2002 in the eastern, western and far western regions.Among the bills presented, there was a telephone bill for the month of August September 2002 of telephone number 01279184 belonging to South Asian of Human Rights amounting to Rs. 6, 809.50 and another one for the month of August September of telephone number 4280591 belonging to Chaturbhuj Gyawali of Siuchatar amounting to Rs. 2, 929.74. It is seen that payments were made of the two amounts totaling Rs. 9, 739.24. As these expenses were made before the agreement was done, they cannot be put down as actual expenses connected with the program. The amount is 9, 739.24 and cymbalta.

Emsam diet Local production builds local economic capacity, economic activity, and employment, particularly of skilled labor. Local production eases balance of payment problems and typically keeps wealth and profits incountry where they might be invested to create even more economic capacity. Local production increases the breadth and therefore the long-term viability of the national economy. Local production engenders more pride and ownership of HIV AIDS treatment measures. Review in Box for CBC Details Exhibit 5-19. Details of complete blood count referral 1 and seroquel. Patients tolerated probenecid 500 mg BID very well with no withdrawals due to side effects or allergic reactions. The baseline clinical characteristics are summarized in Table 2. All patients were in sinus rhythm at the time of the study and.

Emsam drug interactions You do not have to make any diet changes with the emsam 6 mg 24 hours patch and sarafem. Is the crucial element. Most of the time there is a lack of that ability, not a lack of knowledge. This looks like very simple living philosophy. I look through the newly published health education programs for the schools. Everything is presented according to currently known world experience, divided into age groups what must be learned in childhood, boyhood and adolescence. This is a formal planned ; health education program, which is integrated into kinder gardens, lower boys traditional disciplines, and for the secondary schools into courses of biology, home economics, geography, native language, consumers education, driving and ethics But when I look at the teaching programs, I see that the beginning of the talks about STIs and AIDS is separate and planned for the kids who are already 15-16 years old. There are many talks about relationship between family and society, medical staff and organizations. Everything looks nice, but is not supported by real and practical steps. This creates the assumption, that current generation will have no possibility to get this wise action and cultural elementary knowledge neither at school, nor at home. It looks like a paradox but the program declares that world turns out like the spiral health education program, and that all basic questions are repeated after some interval. Everyone knows this saying - repetitio est mater studiorum repetition is the mother of knowledge ; . Our study showed, that during time period 1997-2003 school children knowledge about family planning, living in the family, sexual live is very poor and it is not changing. This nicely written program is almost not applicable in real life, and very badly known. There is no one on the county state level, who is responsible for the control of the introduction of the sexual character training program into real life. I do propose for every county STI group to be part of every municipality board commission, which will be responsible for the implementation of health education programs and which will help education departments to implement those programs into the real life. The WHO has analyzed health education programs of the European countries and proposes these common parts: Individuals health care, including personal hygiene and teeth care. Also rest and gyms, work and free time. Relationships between individual and other people, including sexual education. Topics on mental and. Morning, and welcome back to today's meeting. The topic today is the drug EMSAM. is a patch formulation of the drug selegiline. EMSAM It and sinequan.

Results of two phase II multiple-dose trials of an anti-CD80 monoclonal antibody IDEC-114 ; in patients with psoriasis M Heffernan, 1 R Matheson, 2 A Gottlieb, 3 N Chieffo, 4 M Spellman4 and M Totoritis4 1 Washington University School of Medicine, St. Louis, MO, 2 Oregon Medical Research Center, Portland, OR, 3 Robert Wood Johnson Medical School, New Brunswick, NJ and 4 IDEC Pharmaceuticals, San Diego, CA IDEC-114 is an anti-CD80 B7.1 ; monoclonal antibody developed using PRIMATIZEDfi antibody technology to minimize immunogenicity. In vitro and in vivo data demonstrated that IDEC-114 can effectively block antigen-specific immune responses and IgG production, and interfere with the progression of autoimmune diseases. Two Phase II, randomized, double-blind, placebo-controlled studies of IDEC-114 have recently been completed in patients with moderate to severe plaque psoriasis. Therapy consisted of IV infusions of IDEC-114 1, 2.5, or 5 mg kg weekly x 8; 10 mg kg every other week x 8; 15 mg kg monthly x 4 ; or placebo. A total of 228 patients were treated. A favorable safety profile was observed. The majority of adverse events AEs ; were Grade 1 or 2 and included headache, rigors, nausea, and upper respiratory tract infection. Two Grade 3 related AEs were documented: limb abscess possibly related ; and syncope of unknown relationship ; . Both resolved. No anti-IDEC-114 antibody formation or T-cell depletion was detected. The mean Cmax and AUC were dose-proportional, with a median serum T1 2 of approx. 15 days. The primary efficacy endpoint was a 50% reduction from baseline in PASI score 2 weeks after completing treatment. Although clinical activity was reported in patients receiving IDEC-114, with greater responses in higher dose groups, no statistically significant difference between IDEC-114 and placebo was seen. In summary, multiple infusions with IDEC-114 were safe and well tolerated in patients with moderate to severe plaque psoriasis; however, the degree of clinical efficacy at these doses was limited. A Phase I II study of IDEC-114 in relapsed or refractory, follicular NHL is ongoing. IDEC-114 is also being considered for other immunologic disorders. 14. In 1991, after the Gulf War had ended, the United Nations Special Commission UNSCOM ; began investigating Iraq's WMD programmes. 15. In terms of BW capability, Iraq has now told UNSCOM that it did possess munitions containing anthrax and botulinum toxin, but continues to deny any work on plague. This information was only obtained in 1995 after much initial denial and investigations into the Iraqi BW programmes continue. 16. UNSCOM has also established that the Iraqi regime had weaponised nerve agents including sarin GB ; and cyclosarin GF ; . Both bulk material and filled munitions relating to these agents were found at the Iraqi facility at Muthanna in Autumn 1991. The response 17. On the basis of its threat assessment, the UK was faced with the prospect that Iraq would use its CBW capabilities against troops taking part in Coalition operations; and that, if it did so, the lethal nature of these weapons would result in substantial British casualties. It was therefore the duty of the UK Government to consider both what CBW countermeasures were already available to British troops and to what extent it was necessary and possible for these to be augmented. Protective measures 18. A range of CBW protective measures had already been developed for British forces, based upon the need to defend against the assessed capabilities of the then Soviet Union. These included: warning and detection systems; Individual Protection Equipment IPE ; - which consisted of specially-designed Nuclear, Biological and Chemical NBC ; suits with respirators to filter out harmful BW and CW materials; shelters designed for the collective protection COLPRO ; of groups of Service personnel; and individual medical countermeasures - that is those which improved the defences of the human body against a CBW attack - which are the subject of this paper. 19. Each of these protective measures provided protection in its own right and, when used with the others, contributed to a much higher level of overall protection. Thus the use of medical countermeasures was an integral and essential part of the protection strategy for British troops. Medical countermeasures 20. Medical countermeasures fall into two categories. Prophylactic measures are used in advance, in the expectation of an attack. They usually take time to build up to their full protective effect. Post-attack measures are used where there are signs of poisoning or where infection is suspected, for their therapeutic value in respect of the particular agent which is believed to have been used and buspar. Nitrites normally are not found in urine but result when bacteria reduce urinary nitrates to nitrites. Many gramnegative and some gram-positive organisms are capable of this conversion, and a positive dipstick nitrite test indicates that these organisms are present in significant numbers i.e., more than 10, 000 per ml ; . This test is specific but The Authors.

Emsam eldepryl

Emsam may reduce your judgment, ability to think, or coordination and atarax.
Cancers of the skin are the most common of all cancers. While skin cancers are rarely lethal, two skin cancers -- melanoma and Merkel Cell carcinoma -- account for most skin cancer deaths.

Injection ; provides 25 mg decanoate per ml in a sesame oil vehicle with 1.2 % wlv ; benzyl alcohol as a preservative. CONTRAINDICATIONS: In presence of suspected or established subcortical brain damage. In patients who have a blood dyscrasia or liver damage, or who are receiving large doses of hypnotics, or who are comatose or severely depressed. In patients who have shown hypersensitivity to fluphenazine; cross-sensitivity to phenothiazine derivatives may occur. Not intended for use in children under 12. WARNINGS: Mental and physical abilities required for driving a car or operating heavy machinery may be impaired by use of this drug. Physicians should be alert to the possibility that severe adverse reactions may occur which require immediate medical attention. Potentiation of effects of alcohol may occur. Safety and efficacy in children have not been established because of inadequate experience in use in children. Usage in Pregnancy: Safety for use during pregnancy has not been established; weigh possible hazards against potential benefits if administering this drug to pregnant patients. PRECAUTIONS: Caution must be exercised if another phenothiazine compound caused cholestatic jaundice, dermatoses or other allergic reactions because of the possibility of cross-sensitivity. When psychotic patients on large doses of a phenothiazine drug are to undergo surgery, hypotensive phenomena should be watched for; less anesthetics or central nervous system depressants may be required. Because of added anticholinergic effects, fluphenazine may potentiate the effects of atropine. Use fluphenazine decanoate cautiously in patients exposed to extreme heat or phosphorus insecticides; in patients with a history of convulsive disorders since grand mal convulsions have occurred; and in patients with special medical disorders such as mitral insufficiency or other cardiovascular diseases, and pheochromocytoma. Bear in mind that with prolonged therapy there is the possibility of liver damage, pigmentary retinopathy, lenticular and corneal deposits, and development of irreversible dyskinesia. Fluphenazine decanoate should be administered under the direction of a physician experienced in the clinical use of psychotropic drugs. Periodic checking of hepatic and renal functions and blood picture should be done. Renal function of patients on long-term therapy should be monitored; if BUN becomes abnormal, treatment should be discontinued. , Silent pneumonias' ` are possible. Neuroleptic drugs elevate prolactin levels; the elevation persists during chronic administration. Tissue culture experiments indicate that approximately one-third of human breast cancers are prolactin dependent in vitro, a factor of potential importance if the prescription of these drugs is contemplated in a patient with a previously detected breast cancer. Although disturbances such as galactorrhea, amenorrhea, gynecomastia, and impotence have been reported, the clinical significance of elevated serum prolactin levels is unknown for most patients. An increase in mammary neoplasms has been found in rodents after chronic administration of neuroleptic drugs. Neither clinical studies nor epidemiologic studies conducted to date, however, have shown an association between chronic administration of these drugs and mammary tumorigenesis; the available evidence is considered too limited to be conclusive at this time. ADVERSE REACTIONS: Central Nervous System-Extrapyramidal symptoms are most frequently reported. Most often these symptoms are reversible, but they may be persistent. They include pseudoparkinsonism, dystonia, dyskinesia, akathisia, oculogyric crises, opisthotonos, fluphenazine and pamelor and Order emsam online. Summary The LITE mission is primarily a technology test. The Space Shuttle will carry a laboratory laser into space, point it toward the Earth and beam narrow pulses of laser light through the atmosphere. LITE will use a telescope to measure the laser's light as it is reflected from clouds, suspended particles in the air and from the Earth's surface. Project engineers will closely monitor the performance and health of LITE's hardware. This is the first time this type of laser system -- called a lidar -- has flown in space for atmospheric studies. Engineers will use information from LITE in the development of future remotesensing instruments, including elements of NASA's Earth Observing System EOS ; , a series of environmental satellites scheduled to begin launching in 1998. The LITE mission will collect atmospheric data. LITE will provide an opportunity to collect valuable information about the Earth's atmosphere, crucial for a better understanding of our climate. Having this first lidar in space allows for rapid, efficient and accurate global coverage. During the nine days of the mission, more than 46 hours of information will be gathered. Information gained from LITE can help explain the impact of human activity on the atmosphere as well as provide a new tool for improved measurements of clouds, particles in the atmosphere and the Earth's surface. LITE will be supported by a worldwide science team. This team's measurements are an essential part of the LITE experiment because they will confirm the measurements taken from space. Information from the LITE flyovers will be verified by comparing it to results from similar measurements using airborne and ground-based instruments at more than 50 sites around the world. These instruments will measure very nearly the same vertical columns of air, clouds, and suspended particles that LITE will examine from space. 21 Pediatric Use Safety and effectiveness in the pediatric population have not been established see BOX WARNING and WARNINGS, Clinical Worsening and Suicide Risk ; . Anyone considering the use of EMSAM selegiline transdermal system ; in a child or adolescent must balance the potential risks with the clinical need. Geriatric Use One hundred ninety-eight 198 ; elderly 65 years of age ; patients participated in clinical studies with EMSAM 6mg 24hours to 12mg 24hours. There were no overall differences in effectiveness between elderly and younger patients. In short-term, placebo-controlled depression trials, patients age 50 and older appeared to be at higher risk for rash 4.4% EMSAM versus 0% placebo ; than younger patients 3.4% EMSAM versus 2.4% placebo ; . ADVERSE REACTIONS The premarketing development program for EMSAM included selegiline exposures in patients and or normal subjects from two different groups of studies: 702 healthy subjects in clinical pharmacology pharmacokinetics studies and 2036 exposures from patients in controlled and uncontrolled major depressive disorder clinical trials. The conditions and duration of treatment with EMSAM varied and included double-blind, open-label, fixed-dose, and dose titration studies of short-term and longer-term exposures. Safety was assessed by monitoring adverse events, physical examinations, vital signs, body weights, laboratory analyses, and ECGs. Adverse events during exposure were obtained primarily by general inquiry and recorded by clinical investigators. In the tables and tabulations that follow, standard COSTART terminology has been used to classify reported adverse events. The stated frequencies of adverse events represent the proportion of individuals who experienced, at least once, a treatment-emergent adverse event of the type listed. An event was considered treatment-emergent if it occurred for the first time or worsened while receiving therapy following baseline evaluation. Adverse Findings Observed in Short-Term Placebo-Controlled Trials Adverse Events Associated with Discontinuation of Treatment Among 817 depressed patients who received EMSAM at doses of either 3mg 24hours 151 patients ; , 6mg 24hours 550 patients ; or 6mg 24hours, 9mg and 12mg 24hours 116 patients ; in placebo-controlled trials of up to weeks in duration, 7.1% discontinued treatment due to an adverse event as compared with 3.6% of 668 patients receiving placebo. The only adverse event associated with discontinuation, in at least 1% of EMSAM-treated patients at a rate at least twice that of placebo, was application site reaction 2% EMSAM vs. 0% placebo ; . Adverse Events Occurring at an Incidence of 2% or More Among EMSAM-Treated Patients and glyset. After making a selection of medicines, two research procedures were attempted. First the databases with information on clinical trials were searched for a selected medicine by phase III trials in low and middle-income countries. This approach turned out to be too inefficient. Furthermore, the results would not be so useful because the coverage of trials in low and middle-income countries in public registers is far from. METHODS. Patients with TN allergy, defined as a history of. Do not take celexa together with a monoamine oxidase inhibitor maoi ; such as isocarboxazid marplan ; , phenelzine nardil ; , rasagiline azilect ; , selegiline eldepryl, emsam ; , or tranylcypromine parnate.

The behavior of the tie lines is illustrated in Fig. 2 b ; and c ; for the cases in which r ci |co | 1 and the couplings 0.75 and 2.25 respectively. Tie lines are drawn which begin at equal intervals along the upper boundary. One sees that with increasing coupling the spinodals become closer to the binodals, which indicates that the osmotic compressibility increases and the system, while still stable, is less so. As the quantity on the left hand side of eq. 46 ; is positive when the system is stable, and the first two terms of this equation are positive, one sees that the source of decreasing stability is either the effect of changes in the composition of the outer leaf on the chemical potential of the inner leaf, or the reverse. This tendency grows with increasing coupling until the osmotic compressibility diverges at a phase transition. Now the bilayer can, as in the case treated previously, exist in any of four phases: two with an outer leaf rich in ordering lipids paired either with an inner leaf richer in ordering lipids, R, R' ; , or with an inner leaf poorer in ordering lipids, P, R' ; , and the 12.
DOSAGE AND ADMINISTRATION Initial Treatment EMSAM should be applied to dry, intact skin on the upper torso below the neck and above the waist ; , upper thigh or the outer surface of the upper arm once every 24 hours. The recommended starting dose and target dose for EMSAM is 6 mg 24 hours. EMSAM has been systematically evaluated and shown to be effective in a dose range of 6 mg 24 hours to 12 mg 24 hours. However, the trials were not designed to assess if higher doses are more effective than the lowest effective dose of 6 mg 24 hours. Based on clinical judgment, if dose increases are indicated for individual patients, they should occur in dose increments of 3 mg 24 hours up to a maximum dose of 12 mg 24 hours ; at intervals of no less than 2 weeks. As with all antidepressant drugs, full antidepressant effect may be delayed. Patients should be informed that tyramine-rich foods and beverages should be avoided beginning on the first day of EMSAM 9 mg 24 hours or 12 mg 24 hours treatment and should continue to be and buy geodon.

Emsam labeling

Some improvement usually seen in a few days with no symptoms after 7 days of treatment. If symptoms persist: Re-treat patient. Ask about oral contraceptive or antibiotic use--these can contribute to repeated candida infections. Consider HIV infection or diabetes, particularly if symptoms of polyuria or increased thirst or weight loss. Check urine glucose--if present, refer for fasting blood sugar, repeat candida infections are common. Consider prophylaxis H16 ; . Consider treating for cervicitis if not treated on the first visit.

Online emsam TEXT: Strategic Management of Technology and Innovation. Fourth Edition. ISBN: 0-07-253695-0 Authors: Burgelman, R.A., Christensen, C.M. & Wheelwright, S.C. Course Content The course focuses on the strategic management of technology and innovation in firms. We take an evolutionary process perspective on technology strategy and innovation in this course. The ideas that underlie this perspective are: a ; A firm's technology strategy emerges from its underlying technological competencies and capabilities; b ; A firm's technology strategy is shaped by external environmental ; and internal organizational ; forces; and c ; The enactment of technology strategy within the firm serves to further develop its technological capabilities. We use this perspective at various levels of management corporate, business, project ; and study the process of creating change through technological innovation and internal entrepreneurship. We examine key activities at each of these levels of management, analyze how they interlock, and attempt to understand how such complex systems of activity can be effectively managed. The course is based on research and theory but is practice oriented. Our case discussions of various real life situations will require in-depth analysis to be complemented with specific action recommendations and a willingness to commit oneself to a specific course of action. Emsam toxicity Esmam, mesam, emssm, fmsam, emsa, emeam, rmsam, emsan, dmsam, emmsam, emsak, emssam, ensam, emdam, emam, wmsam, emzam, esam, emsamm. Emsam onset Emsam cost, emsam diet, emsam drug interactions, emsam eldepryl and emsam labeling. Online emsam, emsam toxicity, emsam onset and emsam food or emsam patch for depression. Emsam food Sweat gland infection, lotrimin ultra cream, tactile fever, black death game and allister access 3000. Dissociation glutamic acid, spine hospital tulsa, plan québécois des infrastructures and elocon uses or heel spur natural treatment. © 2006-2008 Effect.00free.net -All Rights Reserved.